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and in cells. We create enhanced potency and selectivity of ULK-one hundred and one compared Along with the printed ULK1 inhibitor, SBI-0206965. In addition, we show that ULK-one hundred and one blocks autophagy induction and suppresses autophagic flux both of those constitutively and in reaction to starvation and mTOR inhibition.Platycodin-D exert